Date of the defence: 5th february 2025

Title of the thesis: Statistical Wavefront Model of Accomodation: Analysis and Synthesis

Brief summary: This thesis investigated wavefront aberrations during accommodation, developed a statistical model, and applied it to computational optical devices. Results showed significant aberration changes with accommodation, especially with mydriatic drugs and different stimuli, but no gender differences. A database of Zernike coefficients was used to create a synthetic wavefront model via Principal Component Analysis, generating realistic synthetic datasets. This model was tested on multifocal contact lenses for myopia control, revealing reduced image quality in both accommodated and non-accommodated states. The synthetic model enables large-scale “in silico” testing, aiding the development and optimization of optical devices.